Institut für Pharmakologie - Allgemeine Pharmakologie

2010

Ho RH, Leake BF, Kilkenny DM, Meyer zu Schwabedissen HE, Glaeser H, Kroetz DL, Kim RB: Polymorphic Variants of the human Bile Salt Export Pump (BSEP, ABCB11): Functional Characterization and Interindividual Variability. Pharmacogenetics and Genomics. 2010; 20(1):45-57
Knauer MJ, Urquhart BL, Meyer zu Schwabedissen H, Schwarz UI, Lemke C, Leake B, Kim RB, Tirona RG: Human Skeletal Muscle Drug Transporters Determine Local Exposure and Toxicity of Statins. Cardiovascular Research 2010 Feb 5;106(2):297-306
Meyer zu Schwabedissen HE, Boettcher K, Chaudhry A, Kroemer HK, Schuetz EG, Kim RB: LXR/alpha; (NR1H3) and FXR (NR1H4) are the major transcriptional regulators of OATP1B1. Hepatology, 2010 Nov;52(5):1797-807
Köck K, Koenen A, Giese B, Fraunholz M, May K, Siegmund W, Hammer E, Völker U, Jedlitschky G, Kroemer HK, Grube M.: Rapid modulation of the organic anion transporting polypeptide 2B1 (OATP2B1, SLCO2B1) function by protein kinase C-mediated internalization. J Biol Chem. 2010 285(15):11336-47
Leonhardt M, Keiser M, Oswald S, Kühn J, Jia J, Grube M, Kroemer HK, Siegmund W, Weitschies W: Hepatic uptake of the magnetic resonance imaging contrast agent Gd-EOB-DTPA: role of human organic anion transporters. Drug Metab Dispos. 2010 38(7):1024-8
Niessen J, Jedlitschky G, Grube M, Kawakami H, Kamiie J, Ohtsuki S, Schwertz H, Bien S, Starke K, Ritter C, Strobel U, Greinacher A, Terasaki T, Kroemer HK: Expression of ABC-type transport proteins in human platelets. Pharmacogenet Genomics 2010. 20(6):396-400
Sotoodehnia N, Isaacs A, de Bakker PI, Dörr M, Newton-Cheh C, Nolte IM, van der Harst P, Müller M, Eijgelsheim M, Alonso A, Hicks AA, Padmanabhan S, Hayward C, Smith AV, Polasek O, Giovannone S, Fu J, Magnani JW, Marciante KD, Pfeufer A, Gharib SA, Teumer A, Li M, Bis JC, Rivadeneira F, Aspelund T, Köttgen A, Johnson T, Rice K, Sie MP, Wang YA, Klopp N, Fuchsberger C, Wild SH, Mateo Leach I, Estrada K, Völker U, Wright AF, Asselbergs FW, Qu J, Chakravarti A, Sinner MF, Kors JA, Petersmann A, Harris TB, Soliman EZ, Munroe PB, Psaty BM, Oostra BA, Cupples LA, Perz S, de Boer RA, Uitterlinden AG, Völzke H, Spector TD, Liu FY, Boerwinkle E, Dominiczak AF, Rotter JI, van Herpen G, Levy D, Wichmann HE, van Gilst WH, Witteman JC, Kroemer HK, Kao WH, Heckbert SR, Meitinger T, Hofman A, Campbell H, Folsom AR, van Veldhuisen DJ, Schwienbacher C, O'Donnell CJ, Volpato CB, Caulfield MJ, Connell JM, Launer L, Lu X, Franke L, Fehrmann RS, te Meerman G, Groen HJ, Weersma RK, van den Berg LH, Wijmenga C, Ophoff RA, Navis G, Rudan I, Snieder H, Wilson JF, Pramstaller PP, Siscovick DS, Wang TJ, Gudnason V, van Duijn CM, Felix SB, Fishman GI, Jamshidi Y, Stricker BH, Samani NJ, Kääb S, Arking DE: Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet. 2010 Dec;42(12):1068-76
Eijgelsheim M, Newton-Cheh C, Sotoodehnia N, de Bakker PI, Müller M, Morrison AC, Smith AV, Isaacs A, Sanna S, Dörr M, Navarro P, Fuchsberger C, Nolte IM, de Geus EJ, Estrada K, Hwang SJ, Bis JC, Rückert IM, Alonso A, Launer LJ, Hottenga JJ, Rivadeneira F, Noseworthy PA, Rice KM, Perz S, Arking DE, Spector TD, Kors JA, Aulchenko YS, Tarasov KV, Homuth G, Wild SH, Marroni F, Gieger C, Licht CM, Prineas RJ, Hofman A, Rotter JI, Hicks AA, Ernst F, Najjar SS, Wright AF, Peters A, Fox ER, Oostra BA, Kroemer HK, Couper D, Völzke H, Campbell H, Meitinger T, Uda M, Witteman JC, Psaty BM, Wichmann HE, Harris TB, Kääb S, Siscovick DS, Jamshidi Y, Uitterlinden AG, Folsom AR, Larson MG, Wilson JF, Penninx BW, Snieder H, Pramstaller PP, van Duijn CM, Lakatta EG, Felix SB, Gudnason V, Pfeufer A, Heckbert SR, Stricker BH, Boerwinkle E, O'Donnell CJ: Genome-wide association analysis identifies multiple loci related to resting heart rate. Hum Mol Genet. 2010 Oct 1;19(19):3885-94
Köttgen A, Pattaro C, Böger CA, Fuchsberger C, Olden M, Glazer NL, Parsa A, Gao X, Yang Q, Smith AV, O'Connell JR, Li M, Schmidt H, Tanaka T, Isaacs A, Ketkar S, Hwang SJ, Johnson AD, Dehghan A, Teumer A, Paré G, Atkinson EJ, Zeller T, Lohman K, Cornelis MC, Probst-Hensch NM, Kronenberg F, Tönjes A, Hayward C, Aspelund T, Eiriksdottir G, Launer LJ, Harris TB, Rampersaud E, Mitchell BD, Arking DE, Boerwinkle E, Struchalin M, Cavalieri M, Singleton A, Giallauria F, Metter J, de Boer IH, Haritunians T, Lumley T, Siscovick D, Psaty BM, Zillikens MC, Oostra BA, Feitosa M, Province M, de Andrade M, Turner ST, Schillert A, Ziegler A, Wild PS, Schnabel RB, Wilde S, Munzel TF, Leak TS, Illig T, Klopp N, Meisinger C, Wichmann HE, Koenig W, Zgaga L, Zemunik T, Kolcic I, Minelli C, Hu FB, Johansson A, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Schreiber S, Aulchenko YS, Felix JF, Rivadeneira F, Uitterlinden AG, Hofman A, Imboden M, Nitsch D, Brandstätter A, Kollerits B, Kedenko L, Mägi R, Stumvoll M, Kovacs P, Boban M, Campbell S, Endlich K, Völzke H, Kroemer HK, Nauck M, Völker U, Polasek O, Vitart V, Badola S, Parker AN, Ridker PM, Kardia SL, Blankenberg S, Liu Y, Curhan GC, Franke A, Rochat T, Paulweber B, Prokopenko I, Wang W, Gudnason V, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, Shlipak MG, van Duijn CM, Borecki I, Krämer BK, Rudan I, Gyllensten U, Wilson JF, Witteman JC, Pramstaller PP, Rettig R, Hastie N, Chasman DI, Kao WH, Heid IM, Fox CS: New loci associated with kidney function and chronic kidney disease. Nat Genet. 2010 May;42(5):376-84
Dörr M, Schmidt CO, Spielhagen T, Bornhorst A, Hentschel K, Franz C, Empen K, Kocher T, Diehl SR, Kroemer HK, Völzke H, Ewert R, Felix SB, Rosskopf D: β-blocker therapy and heart rate control during exercise testing in the general population: role of a common G-protein β-3 subunit variant. Pharmacogenomics. 2010 Sep;11(9):1209-21
Staudt A, Herda LR, Trimpert C, Lubenow L, Landsberger M, Dörr M, Hummel A, Eckerle LG, Beug D, Müller C, Hoffmann W, Weitmann K, Klingel K, Kandolf R, Kroemer HK, Greinacher A, Felix SB: Fcgamma-receptor IIa polymorphism and the role of immunoadsorption in cardiac dysfunction in patients with dilated cardiomyopathy. Clin Pharmacol Ther. 2010 Apr;87(4):452-8
Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens MC, Speliotes EK, Mägi R, Workalemahu T, White CC, Bouatia-Naji N, Harris TB, Berndt SI, Ingelsson E, Willer CJ, Weedon MN, Luan J, Vedantam S, Esko T, Kilpeläinen TO, Kutalik Z, Li S, Monda KL, Dixon AL, Holmes CC, Kaplan LM, Liang L, Min JL, Moffatt MF, Molony C, Nicholson G, Schadt EE, Zondervan KT, Feitosa MF, Ferreira T, Allen HL, Weyant RJ, Wheeler E, Wood AR; MAGIC, Estrada K, Goddard ME, Lettre G, Mangino M, Nyholt DR, Purcell S, Smith AV, Visscher PM, Yang J, McCarroll SA, Nemesh J, Voight BF, Absher D, Amin N, Aspelund T, Coin L, Glazer NL, Hayward C, Heard-Costa NL, Hottenga JJ, Johansson A, Johnson T, Kaakinen M, Kapur K, Ketkar S, Knowles JW, Kraft P, Kraja AT, Lamina C, Leitzmann MF, McKnight B, Morris AP, Ong KK, Perry JR, Peters MJ, Polasek O, Prokopenko I, Rayner NW, Ripatti S, Rivadeneira F, Robertson NR, Sanna S, Sovio U, Surakka I, Teumer A, van Wingerden S, Vitart V, Zhao JH, Cavalcanti-Proença C, Chines PS, Fisher E, Kulzer JR, Lecoeur C, Narisu N, Sandholt C, Scott LJ, Silander K, Stark K, Tammesoo ML, Teslovich TM, Timpson NJ, Watanabe RM, Welch R, Chasman DI, Cooper MN, Jansson JO, Kettunen J, Lawrence RW, Pellikka N, Perola M, Vandenput L, Alavere H, Almgren P, Atwood LD, Bennett AJ, Biffar R, Bonnycastle LL, Bornstein SR, Buchanan TA, Campbell H, Day IN, Dei M, Dörr M, Elliott P, Erdos MR, Eriksson JG, Freimer NB, Fu M, Gaget S, Geus EJ, Gjesing AP, Grallert H, Grässler J, Groves CJ, Guiducci C, Hartikainen AL, Hassanali N, Havulinna AS, Herzig KH, Hicks AA, Hui J, Igl W, Jousilahti P, Jula A, Kajantie E, Kinnunen L, Kolcic I, Koskinen S, Kovacs P, Kroemer HK, Krzelj V, Kuusisto J, Kvaloy K, Laitinen J, Lantieri O, Lathrop GM, Lokki ML, Luben RN, Ludwig B, McArdle WL, McCarthy A, Morken MA, Nelis M, Neville MJ, Paré G, Parker AN, Peden JF, Pichler I, Pietiläinen KH, Platou CG, Pouta A, Ridderstråle M, Samani NJ, Saramies J, Sinisalo J, Smit JH, Strawbridge RJ, Stringham HM, Swift AJ, Teder-Laving M, Thomson B, Usala G, van Meurs JB, van Ommen GJ, Vatin V, Volpato CB, Wallaschofski H, Walters GB, Widen E, Wild SH, Willemsen G, Witte DR, Zgaga L, Zitting P, Beilby JP, James AL, Kähönen M, Lehtimäki T, Nieminen MS, Ohlsson C, Palmer LJ, Raitakari O, Ridker PM, Stumvoll M, Tönjes A, Viikari J, Balkau B, Ben-Shlomo Y, Bergman RN, Boeing H, Smith GD, Ebrahim S, Froguel P, Hansen T, Hengstenberg C, Hveem K, Isomaa B, Jørgensen T, Karpe F, Khaw KT, Laakso M, Lawlor DA, Marre M, Meitinger T, Metspalu A, Midthjell K, Pedersen O, Salomaa V, Schwarz PE, Tuomi T, Tuomilehto J, Valle TT, Wareham NJ, Arnold AM, Beckmann JS, Bergmann S, Boerwinkle E, Boomsma DI, Caulfield MJ, Collins FS, Eiriksdottir G, Gudnason V, Gyllensten U, Hamsten A, Hattersley AT, Hofman A, Hu FB, Illig T, Iribarren C, Jarvelin MR, Kao WH, Kaprio J, Launer LJ, Munroe PB, Oostra B, Penninx BW, Pramstaller PP, Psaty BM, Quertermous T, Rissanen A, Rudan I, Shuldiner AR, Soranzo N, Spector TD, Syvanen AC, Uda M, Uitterlinden A, Völzke H, Vollenweider P, Wilson JF, Witteman JC, Wright AF, Abecasis GR, Boehnke M, Borecki IB, Deloukas P, Frayling TM, Groop LC, Haritunians T, Hunter DJ, Kaplan RC, North KE, O'Connell JR, Peltonen L, Schlessinger D, Strachan DP, Hirschhorn JN, Assimes TL, Wichmann HE, Thorsteinsdottir U, van Duijn CM, Stefansson K, Cupples LA, Loos RJ, Barroso I, McCarthy MI, Fox CS, Mohlke KL, Lindgren CM: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet. 2010 Nov;42(11):949-60
Bien S, Rimmbach C, Neumann H, Niessen J, Reimer E, Ritter CA, Rosskopf D, Cinatl J, Michaelis M, Schroeder HW, Kroemer HK: Doxorubicin-induced cell death requires cathepsin B in HeLa cells. Biochem Pharmacol. 2010 Nov 15;80(10):1466-77
Jedlitschky G, Vogelgesang S, Kroemer HK: MDR1-P-glycoprotein (ABCB1)-mediated disposition of amyloid-β peptides: implications for the pathogenesis and therapy of Alzheimer's disease. Clin Pharmacol Ther. 2010 Oct;88(4):441-443
Schürks M, Neumann FA, Kessler C, Diener HC, Kroemer HK, Kurth T, Völzke H, Rosskopf D: MTHFR 677C>T Polymorphism and Cluster Headache. Headache. 2010. doi: 10.1111/j.1526-4610.2010.01780.x [Epub ahead of print]
Altman RB, Kroemer HK, McCarty CA, Ratain MJ, Roden D: Pharmacogenomics: will the promise be fulfilled? Nat Rev Genet. 2010 Nov 30 [Epub ahead of print].
Luderer F, Lobler M, Rohm HW, Gocke C, Kunna K, Kock K, Kroemer HK, Weitschies W, Schmitz KP, Sternberg K: Biodegradable Sirolimus-loaded Poly(lactide) Nanoparticles as Drug Delivery System for the Prevention of In-Stent Restenosis in Coronary Stent Application. J Biomater Appl. 2010 Mar 17 [Epub ahead of print]
Haring R, Baumeister SE, Völzke H, Dörr M, Felix SB, Kroemer HK, Nauck M, Wallaschofski H: Prospective association of low total testosterone concentrations with an adverse lipid profile and increased incident dyslipidemia. Eur J Cardiovasc Prev Rehabil. 2010 Jun 17 [Epub ahead of print]
Stickel F, Buch S, Lau K, Meyer zu Schwabedissen HE, Berg T, Ridinger M, Rietschel M, Schafmayer C, Braun F, Hinrichsen H, Günther R, Arlt A, Seeger M, Müller S, Seitz HK, Soyka M, Lerch M, Lammert F, Sarrazin C, Kubitz R, Häussinger D, Hellerbrand C, Bröring D, Schreiber S, Kiefer F, Spanagel R, Mann K, Datz C, Krawczak M, Wodarz N, Völzke H, Hampe J: Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians. Hepatology. 2010 Sep 30 [Epub ahead of print]
Rosskopf D, Schwahn C, Neumann F, Bornhorst A, Rimmbach C, Mischke M, Wolf S, Geissler I, Kocher T, Grabe HJ, Nauck M, Hebebrand J, Kroemer HK, Friedrich N, Völzke H, Wallaschofski H: The growth hormone-IGF-I axis as a mediator for the association between FTO variants and body mass index: results of the Study of Health in Pomerania. Int J Obes (Lond). 2010 Aug 24 [Epub ahead of print]
Nambaru PK, Hubner T, Kock K, Mews S, Sendler M, Grube M, Payen L, Guitton J, Jedlitschky G, Rimmbach C, Rosskopf D, Kowalczyk DW, Kroemer HK, Weiss FU, Mayerle J, Lerch MM, Ritter CA: Drug efflux transporter MRP5 affects sensitivity of pancreatic cancer cell lines to the nucleoside anticancer drug 5-fluorouracil. Drug Metab Dispos. 2010 Oct 7 [Epub ahead of print]
Dehghan A, Dupuis J, Barbalic M, Bis JC, Eiriksdottir G, Lu C, Pellikka N, Wallaschofski H, Kettunen J, Henneman P, Baumert J, Strachan DP, Fuchsberger C, Vitart V, Wilson JF, Paré G, Naitza S, Rudock ME, Surakka I, de Geus EJC, Alizadeh BZ, Guralnik J, Shuldiner A, Tanaka T, Zee RYL, Schnabel RB, Vijay Nambi V, Kavousi M, Ripatti S, Nauck M, Smith NL, Smith AV, Sundvall J, Scheet P, Liu Y, Ruokonen A, Rose LM, Larson MG, Hoogeveen RC, Freimer NB, Teumer A, Tracy RP, Launer LJ, Buring JE, Yamamoto JF, Folsom AR, Sijbrands EJG, Pankow J, Elliott P, Keaney JF, Sun W., Sarin A-P, Fontes JD, Badola S., Astor BC, Hofman A, Pouta A, Werdan K, Greiser KH, Kuss O, Meyer zu Schwabedissen HE, Thiery J, Jamshidi Y, I Nolte IM, Soranzo N, Spector TD, Voelzke H, Parker AN, Aspelund T, Bates D, Young L, Tsui K, Siscovick DS, Guo X, Rotter JI, Uda M, Schlessinger D, Rudan I , Hicks AA, Penninx BW, Thorand B, Gieger C, Coresh J, Willemsen G, Harris TB, Uitterlinden AG, Järvelin M-R, Rice K, Radke D, Salomaa V, van Dijk KW, Boerwinkle E, Vasan RS3, Ferrucci L, Quince D, Gibson QD, Bandinelli S, Snieder H, Boomsma DI, Xiao X, Harry Campbell H, Hayward C, Pramstaller PP, van Duijn CM, Peltonen L, Psaty BM, Vilmundur Gudnason V, Ridker PM, Homuth G, Koenig W, Ballantyne CM, Jacqueline CM, Witteman JCM, Benjamin EJ, Perola M, Chasman DI: Meta-analysis of genome-wide association studies in over 80,000 subjects identifies multiple loci for C-reactive protein levels identifies multiple loci for C-reactive protein levels. Circulation accepted 2010 [Epub ahead of print]
Adam O, Lavall D, Theobald K, Hohl M, Grube M, Ameling S, Sussman MA, Rosenkranz S, Kroemer HK, Schafers HJ, Bohm M, Laufs U: Rac1-induced connective tissue growth factor regulates connexin 43 and N-cadherin expression in atrial fibrillation. J.Am.Coll.Cardiol. 2010, 55:469-480.
Hammer E, Bien S, Salazar MG, Steil L, Scharf C, Hildebrandt P, Schroeder HW, Kroemer HK, Volker U, Ritter CA: Proteomic analysis of doxorubicin-induced changes in the proteome of HepG2cells combining 2-D DIGE and LC-MS/MS approaches. Proteomics 2010, 10:99-114.
Hammer E, Phong TQ, Steil L, Klingel K, Salazar MG, Bernhardt J, Kandolf R, Kroemer HK, Felix SB, Volker U: Viral myocarditis induced by Coxsackievirus B3 in A.BY/SnJ mice: Analysis of changes in the myocardial proteome. Proteomics 2010.
Jedlitschky G, Cattaneo M, Lubenow LE, Rosskopf D, Lecchi A, Artoni A, Motta G, Niessen J, Kroemer HK, Greinacher A: Role of MRP4 (ABCC4) in Platelet Adenine Nucleotide-Storage: Evidence from Patients with Delta-Storage Pool Deficiencies. Am.J.Pathol. 2010, 176:1097-1103.
Kroemer HK, Meyer zu Schwabedissen HE: A piece in the puzzle of personalized medicine. Clin Pharmacol Ther., 2010, 87:19-20.
Lucht M, Samochowiec A, Samochowiec J, Jasiewicz A, Grabe HJ, Geissler I, Rimmbach C, Rosskopf D, Grzywacz A, Wysiecka JP, Tybura P, Brzuchalski B, Bienkowski P: Influence of DRD2 and ANKK1 genotypes on apomorphine-induced growth hormone (GH) response in alcohol-dependent patients. Prog.Neuropsychopharmacol.Biol.Psychiatry 2010, 34:45-49.
Meyer zu Schwabedissen HE, Verstuyft C, Kroemer HK, Becquemont L, Kim RB: Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: Functional characterization, interaction with OCT2, and single nucleotide polymorphisms. Am.J.Physiol Renal Physiol 2010.
Rosskopf D, Meyer zu Schwabedissen HE, Kroemer HK, Siegmund W: [Pharmacogenomics in routine medical care]. Dtsch.Med.Wochenschr. 2010, 135:133-144.
Venner M, Peters J, Hohensteiger N, Schock B, Bornhorst A, Grube M, Adam U, Scheuch E, Weitschies W, Rosskopf D, Kroemer HK, Siegmund W: Concentration of the macrolide antibiotic tulathromycin in broncho-alveolar cells is influenced by comedication of rifampicin in foals. Naunyn Schmiedebergs Arch.Pharmacol 2010, 381:161-169.
Volzke H, Alte D, Schmidt CO, Radke D, Lorbeer R, Friedrich N, Aumann N, Lau K, Piontek M, Born G, Havemann C, Ittermann T, Schipf S, Haring R, Baumeister SE, Wallaschofski H, Nauck M, Frick S, Arnold A, Junger M, Mayerle J, Kraft M, Lerch MM, Dorr M, Reffelmann T, Empen K, Felix SB, Obst A, Koch B, Glaser S, Ewert R, Fietze I, Penzel T, Doren M, Rathmann W, Haerting J, Hannemann M, Ropcke J, Schminke U, Jurgens C, Tost F, Rettig R, Kors JA, Ungerer S, Hegenscheid K, Kuhn JP, Kuhn J, Hosten N, Puls R, Henke J, Gloger O, Teumer A, Homuth G, Volker U, Schwahn C, Holtfreter B, Polzer I, Kohlmann T, Grabe HJ, Rosskopf D, Kroemer HK, Kocher T, Biffar R, John U, Hoffmann W: Cohort Profile: The Study of Health in Pomerania. Int.J.Epidemiol. 2010.

2009

Friedrich N, Rosskopf D, Brabant G, Volzke H, Nauck M, Wallaschofski H: Associations of Anthropometric Parameters with Serum TSH, Prolactin, IGF-I, and Testosterone Levels: Results of the Study of Health in Pomerania (SHIP). Exp.Clin Endocrinol.Diabetes 2009.
Friedrich N, Haring R, Nauck M, Ludemann J, Rosskopf D, Spilcke-Liss E, Felix SB, Dorr M, Brabant G, Volzke H, Wallaschofski H: Mortality and serum insulin-like growth factor (IGF)-I and IGF binding protein 3 concentrations. J.Clin Endocrinol.Metab 2009, 94:1732-1739.
Fuchshuber-Moraes M, Perini JA, Rosskopf D, Suarez-Kurtz G: Exploring warfarin pharmacogenomics with the extreme-discordant-phenotype methodology: impact of FVII polymorphisms on stable anticoagulation with warfarin. Eur.J.Clin Pharmacol 2009, 65:789-793.
Grabe HJ, Spitzer C, Schwahn C, Marcinek A, Frahnow A, Barnow S, Lucht M, Freyberger HJ, John U, Wallaschofski H, Volzke H, Rosskopf D: Serotonin transporter gene (SLC6A4) promoter polymorphisms and the susceptibility to posttraumatic stress disorder in the general population. Am.J.Psychiatry 2009, 166:926-933.
Grisk O, Steinbach AC, Ciecholewski S, Schluter T, Kloting I, Schmidt H, Dazert E, Schaeffeler E, Steil L, Gauer S, Jedlitschky G, Schwab M, Geisslinger G, Hauser IA, Volker U, Kroemer HK, Rettig R: Multidrug resistance-related protein 2 genotype of the donor affects kidney graft function. Pharmacogenet.Genomics 2009, 19:276-288.
Guo Y, Kock K, Ritter CA, Chen ZS, Grube M, Jedlitschky G, Illmer T, Ayres M, Beck JF, Siegmund W, Ehninger G, Gandhi V, Kroemer HK, Kruh GD, Schaich M: Expression of ABCC-type nucleotide exporters in blasts of adult acute myeloid leukemia: relation to long-term survival. Clin Cancer Res. 2009, 15:1762-1769.
Haring R, Volzke H, Felix SB, Schipf S, Dorr M, Rosskopf D, Nauck M, Schofl C, Wallaschofski H: Prediction of metabolic syndrome by low serum testosterone levels in men: results from the study of health in Pomerania. Diabetes 2009, 58:2027-2031.
Lucht M, Samochowiec A, Samochowiec J, Jasiewicz A, Grabe HJ, Geissler I, Rimmbach C, Rosskopf D, Grzywacz A, Wysiecka JP, Tybura P, Brzuchalski B, Bienkowski P: Influence of DRD2 and ANKK1 genotypes on apomorphine-induced growth hormone (GH) response in alcohol-dependent patients. Prog.Neuropsychopharmacol.Biol.Psychiatry 2009.
Lucht MJ, Barnow S, Sonnenfeld C, Rosenberger A, Grabe HJ, Schroeder W, Volzke H, Freyberger HJ, Herrmann FH, Kroemer H, Rosskopf D: Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects. Prog.Neuropsychopharmacol.Biol.Psychiatry 2009, 33:860-866.
Meisinger C, Prokisch H, Gieger C, Soranzo N, Mehta D, Rosskopf D, Lichtner P, Klopp N, Stephens J, Watkins NA, Deloukas P, Greinacher A, Koenig W, Nauck M, Rimmbach C, Volzke H, Peters A, Illig T, Ouwehand WH, Meitinger T, Wichmann HE, Doring A: A genome-wide association study identifies three loci associated with mean platelet volume. Am.J.Hum.Genet. 2009, 84:66-71.
Niessen J, Jedlitschky G, Grube M, Bien S, Schwertz H, Ohtsuki S, Kawakami H, Kamiie J, Oswald S, Starke K, Strobel U, Siegmund W, Rosskopf D, Greinacher A, Terasaki T, Kroemer HK: Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin. Drug Metab Dispos. 2009, 37:1129-1137.
Oevermann L, Scheitz J, Starke K, Kock K, Kiefer T, Dolken G, Niessen J, Greinacher A, Siegmund W, Zygmunt M, Kroemer HK, Jedlitschky G, Ritter CA: Hematopoietic stem cell differentiation affects expression and function of MRP4 (ABCC4), a transport protein for signaling molecules and drugs. Int.J.Cancer 2009, 124:2303-2311.
Riad A, Bien S, Westermann D, Becher PM, Loya K, Landmesser U, Kroemer HK, Schultheiss HP, Tschope C: Pretreatment with statin attenuates the cardiotoxicity of Doxorubicin in mice. Cancer Res. 2009, 69:695-699.
Rosskopf D, Kroemer HK, Siegmund W: [Pharmacokinetic problems in clinical practice: role of drug transporters]. Dtsch.Med.Wochenschr. 2009, 134:345-356.
Ufer M, Mosyagin I, Muhle H, Jacobsen T, Haenisch S, Hasler R, Faltraco F, Remmler C, von Spiczak S, Kroemer HK, Runge U, Boor R, Stephani U, Cascorbi I: Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C>T polymorphism in young and adult patients with epilepsy. Pharmacogenet.Genomics 2009, 19:353-362.
Vasan RS, Glazer NL, Felix JF, Lieb W, Wild PS, Felix SB, Watzinger N, Larson MG, Smith NL, Dehghan A, Grosshennig A, Schillert A, Teumer A, Schmidt R, Kathiresan S, Lumley T, Aulchenko YS, Konig IR, Zeller T, Homuth G, Struchalin M, Aragam J, Bis JC, Rivadeneira F, Erdmann J, Schnabel RB, Dorr M, Zweiker R, Lind L, Rodeheffer RJ, Greiser KH, Levy D, Haritunians T, Deckers JW, Stritzke J, Lackner KJ, Volker U, Ingelsson E, Kullo I, Haerting J, O'Donnell CJ, Heckbert SR, Stricker BH, Ziegler A, Reffelmann T, Redfield MM, Werdan K, Mitchell GF, Rice K, Arnett DK, Hofman A, Gottdiener JS, Uitterlinden AG, Meitinger T, Blettner M, Friedrich N, Wang TJ, Psaty BM, van Duijn CM, Wichmann HE, Munzel TF, Kroemer HK, Benjamin EJ, Rotter JI, Witteman JC, Schunkert H, Schmidt H, Volzke H, Blankenberg S: Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. JAMA 2009, 302:168-178.
Vogel CI, Scherag A, Bronner G, Nguyen TT, Wang HJ, Grallert H, Bornhorst A, Rosskopf D, Volzke H, Reinehr T, Rief W, Illig T, Wichmann HE, Schafer H, Hebebrand J, Hinney A: Gastric inhibitory polypeptide receptor: association analyses for obesity of several polymorphisms in large study groups. BMC.Med.Genet. 2009, 10:19.
Volzke H, Bornhorst A, Rimmbach C, Petersenn H, Geissler I, Nauck M, Wallaschofski H, Kroemer HK, Rosskopf D: Common variants in the G protein beta3 subunit gene and thyroid disorders in a formerly iodine-deficient population. Thyroid 2009, 19:1115-1119.
Volzke H, Aumann N, Krebs A, Nauck M, Steveling A, Lerch MM, Rosskopf D, Wallaschofski H: Hepatic steatosis is associated with low serum testosterone and high serum DHEAS levels in men. Int.J.Androl 2009.

2008

Agmo H, V, Niessen J, Harnisch F, Block S, Greinacher A, Kroemer HK, Helm CA, Scholz F: The adhesion and spreading of thrombocyte vesicles on electrode surfaces. Bioelectrochemistry. 2008, 74:210-216.
Doring A, Gieger C, Mehta D, Gohlke H, Prokisch H, Coassin S, Fischer G, Henke K, Klopp N, Kronenberg F, Paulweber B, Pfeufer A, Rosskopf D, Volzke H, Illig T, Meitinger T, Wichmann HE, Meisinger C: SLC2A9 influences uric acid concentrations with pronounced sex-specific effects. Nat.Genet. 2008, 40:430-436.
Friedrich N, Volzke H, Rosskopf D, Steveling A, Krebs A, Nauck M, Wallaschofski H: Reference ranges for serum dehydroepiandrosterone sulfate and testosterone in adult men. J.Androl 2008, 29:610-617.
Gradhand U, Lang T, Schaeffeler E, Glaeser H, Tegude H, Klein K, Fritz P, Jedlitschky G, Kroemer HK, Bachmakov I, Anwald B, Kerb R, Zanger UM, Eichelbaum M, Schwab M, Fromm MF: Variability in human hepatic MRP4 expression: influence of cholestasis and genotype. Pharmacogenomics J. 2008, 8:42-52.
Landsberger M, Staudt A, Choudhury S, Trimpert C, Herda LR, Klingel K, Kandolf R, Schultheiss HP, Kroemer HK, Volker U, Felix SB: Potential role of antibodies against cardiac Kv channel-interacting protein 2 in dilated cardiomyopathy. Am.Heart J. 2008, 156:92-99.
Lucht M, Rosskopf D: Comment on "Genetically determined differences in learning from errors". Science 2008, 321:200.
Maas O, Donat U, Frenzel M, Rutz T, Kroemer HK, Felix SB, Krieg T: Vardenafil protects isolated rat hearts at reperfusion dependent on GC and PKG. Br.J.Pharmacol 2008, 154:25-31.
May K, Minarikova V, Linnemann K, Zygmunt M, Kroemer HK, Fusch C, Siegmund W: Role of the multidrug transporter proteins ABCB1 and ABCC2 in the diaplacental transport of talinolol in the term human placenta. Drug Metab Dispos. 2008, 36:740-744.
Neubert A, Sternberg K, Nagel S, Harder C, Schmitz KP, Kroemer HK, Weitschies W: Development of a vessel-simulating flow-through cell method for the in vitro evaluation of release and distribution from drug-eluting stents. J.Control Release 2008, 130:2-8.
Oswald S, Konig J, Lutjohann D, Giessmann T, Kroemer HK, Rimmbach C, Rosskopf D, Fromm MF, Siegmund W: Disposition of ezetimibe is influenced by polymorphisms of the hepatic uptake carrier OATP1B1. Pharmacogenet.Genomics 2008, 18:559-568.
Riad A, Bien S, Gratz M, Escher F, Westermann D, Heimesaat MM, Bereswill S, Krieg T, Felix SB, Schultheiss HP, Kroemer HK, Tschope C: Toll-like receptor-4 deficiency attenuates doxorubicin-induced cardiomyopathy in mice. Eur.J.Heart Fail. 2008, 10:233-243.
Rosskopf D, Michel MC: Pharmacogenomics of G protein-coupled receptor ligands in cardiovascular medicine. Pharmacol Rev. 2008, 60:513-535.
Sonnemann J, Huls I, Sigler M, Palani CD, Hong lT, Volker U, Kroemer HK, Beck JF: Histone deacetylase inhibitors and aspirin interact synergistically to induce cell death in ovarian cancer cells. Oncol.Rep. 2008, 20:219-224.
Hoffmann, U, Abel, P, Hecker, U: Acute poisoning by pirimicarb: clinical and toxicological features. Clin. Toxicol.(Phila), 46 (7):694-696
Rochow, N, Küster, H, Bandt, C, Hoffmann, U, Fusch, C: Case 1: Unexpected muscular hypotonia and need for mechanical ventilation in a preterm infant (Case Presentation). Acta Paediatr. 97 (12):1602-3
Rochow, N, Küster, H, Bandt, C, Hoffmann, U, Fusch, C: Case 1: Unexpected muscular hypotonia and need for mechanical ventilation in a preterm infant (Discussion and Diagnosis). Acta Paediatr. 97 (12):1758-9
Hoffmann, U, Abel, P, Neurarath, H: Acute ethylene glycol poisoning after intentional ingestion. Toxichem. Krimtech 75 (3):130-133
Hoffmann, U, Cascorbi, I: The impact of Cytochrome P450 2D6 and UDP-glucuronosyl-transferase 1A1 genotypes for the toxicity of antidepressants and tranquilizers. XV. GTFCh-Symposium 2007, Praxis der Forensischen Toxikologie, ed. by F. Pragst, R. Aderjan Bad Vilbel 2008, 184-192

2007

Hoffmann, U, Moll, A: Entwicklung des Alkohol- und Drogenmißbrauches im Raum Greifswald/Vorpommern. Ärzteblatt MV 6, 199-201 (2007)
Meissner K, Kessler W, Meyer Zu Schwabedissen HE, Schuster K, Saalfeld K, Grube M, Buck A, Jedlitschky G, Maier S, Traeger T, Mostertz J, Homuth G, Heidecke CD, Lehmann C, Kroemer HK: Sepsis affects cardiac expression of Multidrug Resistance Protein 5 (MRP5, ABCC5), an ABC-type cGMG export pump. Shock. 2007 Jun 21 [Epub ahead of print]
Kuhnke D, Jedlitschky G, Grube M, Krohn M, Jucker M, Mosyagin I, Cascorbi I, Walker LC, Kroemer HK, Warzok RW, Vogelgesang S: MDR1-P-Glycoprotein (ABCB1) Mediates Transport of Alzheimer's Amyloid-beta Peptides-Implications for the Mechanisms of Abeta Clearance at the Blood-Brain Barrier. Brain Pathol. 2007 Jul 4 [Epub ahead of print]
Kock K, Grube M, Jedlitschky G, Oevermann L, Siegmund W, Ritter CA, Kroemer HK: Expression of adenosine triphosphate-binding cassette (ABC) drug transporters in peripheral blood cells: relevance for physiology and pharmacotherapy. Clin Pharmacokinet. 2007:46(6):449-70:125-142
Reimer J, Bien S, Sonnemann J, Beck JF, Wieland T, Kroemer HK, Ritter CA: Reduced expression of Rho guanine nucleotide dissociation inhibitor-alpha modulates the cytotoxic effect of busulfan in HEK293 cells. Anticancer Drugs. 2007:18(3):333-40
Rosskopf D, Bornhorst A, Rimmbach C, Schwahn C, Kayser A, Kruger A, Tessmann G, Geissler I, Kroemer HK, Volzke H: Comment on "A common genetic variant is associated with adult and childhood obesity". Science. 2007315(5809):187
Meisel P, Kohlmann T, Kocher T: Association of height with inflammation and periodontitis: the Study of Health in Pomerania. Clin Periodontol. 2007:34(5):390-6
Schurks M, Kurth T, Stude P, Rimmbach C, de Jesus J, Jonjic M, Diener HC, Rosskopf D: G Protein b3 Polymorphism and Triptan Response in Cluster Headache. Clin Pharmacol Ther. 2007 Mar 14 [Epub ahead of print]
Rosskopf D, Schurks M, Rimmbach C, Schafers R: Genetics of arterial hypertension and hypotension. Naunyn Schmiedebergs Arch Pharmacol. 2007:374(5-6):429-69
Schurks M, Kurth T, Geissler I, Tessmann G, Diener HC, Rosskopf D: The G1246A polymorphism in the hypocretin receptor 2 gene is not associated with treatment response in cluster headache. Cephalalgia. 2007:27(4):363-7
Schurks M, Rosskopf D, de Jesus J, Jonjic M, Diener HC, Kurth T: Predictors of acute treatment response among patients with cluster headache. Headache. 2007:47(7):1079-84
Buch S, Schafmayer C, Volzke H, Becker C, Franke A, von Eller-Eberstein H, Kluck C, Bassmann I, Brosch M, Lammert F, Miquel JF, Nervi F, Wittig M, Rosskopf D, Timm B, Holl C, Seeger M, ElSharawy A, Lu T, Egberts J, Fandrich F, Folsch UR, Krawczak M, Schreiber S, Nurnberg P, Tepel J, Hampe J: A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease. Nat Genet. 200739(8):995-9

2006

Grube M, Kock K, Karner S, Reuther S, Ritter CA, Jedlitschky G, Kroemer HK: Modification of OATP2B1-mediated transport by steroid hormones. Mol Pharmacol. 2006:70(5):1735-41
Dazert P, Suofu Y, Grube M, Popa-Wagner A, Kroemer HK, Jedlitschky G, Kessler C: Differential regulation of transport proteins in the periinfarct region following reversible middle cerebral artery occlusion in rats. Neuroscience. 2006:142(4):1071-9
Grube M, Reuther S, Meyer Zu Schwabedissen H, Kock K, Draber K, Ritter CA, Fusch C, Jedlitschky G, Kroemer HK: Organic anion transporting polypeptide 2B1 and breast cancer resistance protein interact in the transepithelial transport of steroid sulfates in human placenta. Metab Dispos. 2007:35(1):30-5
Grube M, Kock K, Oswald S, Draber K, Meissner K, Eckel L, Bohm M, Felix SB, Vogelgesang S, Jedlitschky G, Siegmund W, Warzok R, Kroemer HK: Organic anion transporting polypeptide 2B1 is a high-affinity transporter for atorvastatin and is expressed in the human heart. Pharmacol Ther. 2006:80(6):607-20
Oswald S, Giessmann T, Luetjohann D, Wegner D, Rosskopf D, Weitschies W, Siegmund W: Disposition and sterol-lowering effect of ezetimibe are influenced by single-dose coadministration of rifampin, an inhibitor of multidrug transport proteins. Clin Pharmacol Ther. 2006:80(5):477-85
Schurks M, Kurth T, de Jesus J, Jonjic M, Rosskopf D, Diener HC: Cluster headache: clinical presentation, lifestyle features, and medical treatment. Headache. 2006:46(8):1246-54
Lopez De Jesus M, Stope MB, Oude Weernink PA, Mahlke Y, Borgermann C, Ananaba VN, Rimmbach C, Rosskopf D, Michel MC, Jakobs KH, Schmidt M: Cyclic AMP-dependent and Epac-mediated activation of R-Ras by G protein-coupled receptors leads to phospholipase D stimulation. J Biol Chem. 2006:281(31):21837-47
Schurks M, Kurth T, Geissler I, Tessmann G, Diener HC, Rosskopf D: Cluster headache is associated with the G1246A polymorphism in the hypocretin receptor 2 gene. Neurology. 2006:66(12):1917-9
Hoffmann U: Transport of Xenobiotics and toxicants by multidrug resistance protein MDR1 and related transporters. XIV. GTFCh-Symposium 2005, Praxis der Forensischen Toxikologie, ed. by F. Pragst, R. Aderjan, Verl. D. Helm, Heppenheim 2006:125-142
Below E., Papendorf T, Hoffmann U: Clinical and toxicological data in acute parathion and dimethoate poisonings. XIV. GTFCh-Symposium 2005, Praxis der Forensischen Toxikologie, ed. by F. Pragst, R. Aderjan, Verl. D. Helm, Heppenheim 2006:507-521
Hoffmann U, Papendorf T: Organophosphate poisonings with parathion and dimethoate. Intens. Care Med. 2006:32:464-468
Meisel P, Giebel J, Kunert-Keil C, Dazert P, Kroemer HK, Kocher T: MDR1 gene polymorphisms and risk of gingival hyperplasia induced by calcium antagonists. Clin Pharmacol Therap 2006:79(1):62-71
Grube M, Meyer zu Schwabedissen HE, Präger D, Haney J, Möritz K-U, Meissner K, Rosskopf D, Eckel L, Böhm M, Jedlitschky G, Kroemer HK: Uptake of Cardiovascular Drugs into Human Heart: Expression, Regulation and Function of the Carnitine Transporter OCTN2 (SLC22A5). Circulation 2006:113(8):1114-1122
Meyer Zu Schwabedissen HE, Dreisbach A, Hammer E, Fusch C, Hecker M, Volker U, Kroemer HK: Direct mass spectrometric identification of ABCB1 (P-glycoprotein/MDR1) from the apical membrane fraction of human placenta using fourier transform ion cyclotron mass spectrometry. Pharmacogenet Genomics. 2006:385-389
Meyer zu Schwabedissen HE, Grube M, Dreisbach A, Jedlitschky G, Meissner K, Linnemann K, Fusch C, Ritter CA, Volker U, Kroemer HK: Epidermal growth factor-mediated activation of the map kinase cascade results in altered expression and function of abcg2 (bcrp). Drug Metab Dispos. 2006:524-533
Meissner K, Heydrich B, Jedlitschky G, Meyer Zu Schwabedissen H, Mosyagin I, Dazert P, Eckel L, Vogelgesang S, Warzok RW, Bohm M, Lehmann C, Wendt M, Cascorbi I, Kroemer HK: The ATP-binding cassette transporter ABCG2 (BCRP), a marker for side population stem cells, is expressed in human heart. PJ Histochem Cytochem. 2006:215-221
Jedlitschky G, Hoffmann U & Kroemer HK: Structure and function of the MRP2 (ABCC2) protein and its role in drug disposition. Expert Opin. Drug Metab. Toxicol. 2006:in press

2005

Meisel P, Schwahn C, Luedemann J, John U, Kroemer HK, Kocher T: Magnesium deficiency is associated with periodontal disease. J Dent Res 2005:84:10:937-941
Meisel P: Hypertension, diabetes: chocolate with a single remedy?. Hypertension 2005:46:5:e17
Meisel P, Schwahn C, John U, Kroemer HK, Kocher T: Calcium antagonists and deep gingival pockets in the population-based SHIP study. Br J Clin Pharmacol 2005:60:5:552-559
Meisel P, Kocher T: Photodynamic therapy for periodontal diseases: state of the art. J Photochem Photobiol B 2005:79:2:159-170
Hoffmann, U., Przybilla, Kraatz, G.: Cholestasis in a body-builder after use of metandienone – a case report. Toxichem. Krimtech. 2005:72(3):115-117
Schwabedissen HM, Jedlitschky G, Gratz M, Haenisch S, Linnemann K, Fusch C, Cascorbi I, Kroemer HK: Variable expression of MRP2 (ABCC2) in human placenta: influence of gestational age and cellular differentiation. Drug Metab Dispos 2005:33:7:896-904
Grube M, Schwabedissen HM, Draber K, Prager D, Moritz KU, Linnemann K, Fusch C, Jedlitschky G, Kroemer HK: Expression, localization, and function of the carnitine transporter octn2 (slc22a5) in human placenta. Drug Metab Dispos 2005:33:1:31-37
Schwabedissen HM, Grube M, Heydrich B, Linnemann K, Fusch C, Kroemer HK, Jedlitschky G: Expression, localization, and function of MRP5 (ABCC5), a transporter for cyclic nucleotides, in human placenta and cultured human trophoblasts: effects of gestational age and cellular differentiation. Am J Pathol 2005:166:1:39-48
Gratz M, Kunert-Keil C, John U, Cascorbi I, Kroemer HK: Identification and functional analysis of genetic variants of the human beta-glucuronidase in a German population sample. Pharmacogenet Genomics 2005:15:12:875-881
Meissner K, Heydrich B, Jedlitschky G, Schwabedissen HM HM, Mosyagin I, Dazert P, Eckel L, Vogelgesang S, Warzok RW, Bohm M, Lehmann C, Wendt M, Cascorbi I, Kroemer HK: The ATP-binding Cassette Transporter ABCG2 (BCRP), a Marker for Side Population Stem Cells, is Expressed in Human Heart. J Histochem Cytochem 2005
Ritter CA, Jedlitschky G, Schwabedissen HM, Grube M, Kock K, Kroemer HK: Cellular export of drugs and signaling molecules by the ATP-binding cassette transporters MRP4 (ABCC4) and MRP5 (ABCC5). Drug Metab Rev 2005:37:1:253-278
Timm R, Kaiser R, Lotsch J, Heider U, Sezer O, Weisz K, Montemurro M, Roots I, Cascorbi I: Association of cyclophosphamide pharmacokinetics to polymorphic cytochrome P450 2C19. Pharmacogenomics J 2005:5:6:365-373

2004

Schwabedissen HM, Kroemer HK: [Ezetimib]. Dtsch Med Wochenschr 2004.:2038-2040
Cascorbi I, Paul M, Kroemer HK: Pharmacogenomics of heart failure -- focus on drug disposition and action. Cardiovasc Res 2004:64:1:32-39
Hoffmann, U., Kuno, S., Franke, G., Fusch, C., Haas, J.P.: Adrenoceptor ago¬nist poisoning after accidental oral ingestion of brimonidine drops. Pediatr.Crit.Care Med. 2004:5:282-285
Hoffmann, U., Franke, G., Kuno, S., Haas, J.P.: Systemic α₂-adrenergic agonist poisoning with Alphagan eye drops after oral ingestion in an infant. GTFCh-Symposium 2003, Ausgewählte Aspekte der Forensischen Toxikologie, ed. by F. Pragst, R. Aderjan, Verl. D. Helm, Heppenheim 2004:129-138
Hoffmann U, Kroemer HK: The ABC transporters MDR1 and MRP2: multiple functions in disposition of xenobiotics and drug resistance. Drug Metab Rev 2004:36:03. Apr:669-701
Bien S, Ritter CA, Kranz M, Scharf C, Steil L, Hummel M, Volker U, Cascorbi I, Kroemer HK: Influence of doxorubicin on gene expression and protein pattern in HeLa cells. Int J Clin Pharmacol Ther 2004:42:11:640-641
Kunert-Keil C, Sperker B, Bien S, Wolf G, Grube M, Kroemer HK: Involvement of AP-2 binding sites in regulation of human beta-glucuronidase. Naunyn Schmiedebergs Arch Pharmacol 2004:370:5:331-339
Bien S, Ritter CA, Gratz M, Sperker B, Sonnemann J, Beck JF, Kroemer HK: Nuclear factor-kappaB mediates up-regulation of cathepsin B by doxorubicin in tumor cells. Mol Pharmacol 2004:65:5:1092- 1102
Meissner K, Jedlitschky G, Schwabedissen HM, Dazert P, Eckel L, Vogelgesang S, Warzok RW, Bohm M, Lehmann C, Wendt M, Cascorbi I, Kroemer HK: Modulation of multidrug resistance P-glycoprotein 1 (ABCB1) expression in human heart by hereditary polymorphisms. Pharmacogenetics 2004:14:6:381-385
Meisel P, Schwahn C, Gesch D, Bernhardt O, John U, Kocher T: Dose-effect relation of smoking and the interleukin-1 gene polymorphism in periodontal disease. J Periodontol 2004:75:2:236-242
Jedlitschky G, Tirschmann K, Lubenow LE, Nieuwenhuis HK, Akkerman JW, Greinacher A, Kroemer HK: The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage. Blood 2004:104:12:3603-3610
Mosyagin I, Dettling M, Roots I, Mueller-Oerlinghausen B, Cascorbi I: Impact of myeloperoxidase and NADPH-oxidase polymorphisms in drug-induced agranulocytosis. J Clin Psychopharmacol 2004:24:6:613-617

2003

Dressel D, Ritter CA, Sperker B, Grube M, Maier T, Klingebiel T, Siegmund W, Beck JF, Kroemer HK: Busulfan induces activin A expression in vitro and in vivo: a possible link to venous occlusive disease. Clin Pharmacol Ther 2003:74:3:264-274
Dazert P, Meissner K, Vogelgesang S, Heydrich B, Eckel L, Bohm M, Warzok R, Kerb R, Brinkmann U, Schaeffeler E, Schwab M, Cascorbi I, Jedlitschky G, Kroemer HK: Expression and localization of the multidrug resistance protein 5 (MRP5/ABCC5), a cellular export pump for cyclic nucleotides, in human heart. Am J Pathol 2003:163:4:1567-1577
Cascorbi I: Pharmacogenetics of cytochrome p4502D6: genetic background and clinical implication. Eur J Clin Invest 2003:33:Suppl 2:17-22
Meisel P, Siegemund A, Grimm R, Herrmann FH, John U, Schwahn C, Kocher T: The interleukin-1 polymorphism, smoking, and the risk of periodontal disease in the population-based SHIP study. J Dent Res 2003:82:3:189-193
Meisel P, Kocher T: Risk factors in periodontitis and classifying the disease. Eur J Oral Sci 2003:111:3:280-281
Grube M, Kunert-Keil C, Sperker B, Kroemer HK: Verapamil regulates activity and mRNA-expression of human beta-glucuronidase in HepG2 cells. Naunyn Schmiedebergs Arch Pharmacol 2003:368:6:463-469
Popowski K, Sperker B, Kroemer HK, John U, Laule M, Stangl K, Cascorbi I: Functional significance of a hereditary adenine insertion variant in the 5'-UTR of the endothelin-1 gene. Pharmacogenetics 2003:13:8:445-451
Brodde OE, Kroemer HK: Drug-drug interactions of beta-adrenoceptor blockers. Arzneimittelforschung 2003:53:12:814-822
Ritter CA, Kroemer HK: [What should be considered in the administration of cholesterol synthesis enzyme inhibitors? Interaction and adverse effect potentials of statins]. Pharm Unserer Zeit 2003:32:6:490-497

2002

Meissner K, Sperker B, Karsten C, Schwabedissen HM, Seeland U, Bohm M, Bien S, Dazert P, Kunert-Keil C, Vogelgesang S, Warzok R, Siegmund W, Cascorbi I, Wendt M, Kroemer HK: Expression and localization of P-glycoprotein in human heart: effects of cardiomyopathy. J Histochem Cytochem 2002:50:10:1351-1356
Meisel P: Arylamine N-acetyltransferases and drug response. Pharmacogenomics 2002:3:3:349- 366
Meisel P, Giebel J, Peters M, Foerster K, Cascorbi I, Wulff K, Fanghaenel J, Kocher T: Expression of N-acetyltransferases in periodontal granulation tissue. J Dent Res 2002:81:5:349-353
Meisel P: Cancer, genes and gender. Carcinogenesis 2002:23:6:1087-1088
Kocher T, Sawaf H, Fanghanel J, Timm R, Meisel P: Association between bone loss in periodontal disease and polymorphism of N-acetyltransferase (NAT2). J Clin Periodontol 2002:29:1:21-27
Meisel P, Siegemund A, Dombrowa S, Sawaf H, Fanghaenel J, Kocher T: Smoking and polymorphisms of the interleukin-1 gene cluster (IL-1alpha, IL-1beta, and IL-1RN) in patients with periodontal disease. J Periodontol 2002:73:1:27-32
Ritter CA, Sperker B, Grube M, Dressel D, Kunert-Keil C, Kroemer HK : Overexpression of glutathione S-transferase A1-1 in ECV 304 cells protects against busulfan mediated G2-arrest and induces tissue factor expression. Br J Pharmacol 2002:137:7:1100-1106
Sperker B, Murdter TE, Backman JT, Fritz P, Kroemer HK: Expression of active human beta-glucuronidase in Sf9 cells infected with recombinant baculovirus. Life Sci 2002:71:13:1547-1557
Meisel P, Krause T, Cascorbi I, Schroeder W, Herrmann F, John U, Kocher T: Gender and smoking-related risk reduction of periodontal disease with variant myeloperoxidase alleles. Genes Immun 2002:3:2:102-106