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Abt. Allgemeine
Pharmakologie

2011
  • Oswald S, Schumacher G, Siegmund W: Quantitative determination of methylnaltrexone in human serum using liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal 2011.

  • Peters J, Block W, Oswald S, Freyer J, Grube M, Kroemer HK, Lammer M, Lutjohann D, Venner M, Siegmund W: Oral absorption of clarithromycin is nearly abolished by chronic comedication of rifampicin in foals. Drug Metab Dispos 2011, 39:1643-1649.

  • Siegmund W, Siegert J, Richter K, Schnabel F, Feustel C, Kirch W: Influence of a Fat-Rich Meal on Bioavailability of Extended-Release and Immediate-Release Propiverine. J Clin Pharmacol 2011.

  • Oswald S, Nassif A, Modess C, Keiser M, Ulrich A, Runge D, Hanke U, Lutjohann D, Engel A, Weitschies W, Siegmund W: Drug interactions between the immunosuppressant tacrolimus and the cholesterol absorption inhibitor ezetimibe in healthy volunteers. Clin Pharmacol Ther 2011, 89:524-528.

  • May K, Rosenlof L, Olsson MG, Centlow M, Morgelin M, Larsson I, Cederlund M, Rutardottir S, Siegmund W, Schneider H, Akerstrom B, Hansson SR: Perfusion of human placenta with hemoglobin introduces preeclampsia-like injuries that are prevented by alpha1-microglobulin. Placenta 2011, 32:323-332.

  • Weiss M, Sermsappasuk P, Siegmund W: Modeling the Kinetics of Digoxin Absorption: Enhancement by P-Glycoprotein Inhibition. J Clin Pharmacol 2011.

  • Oswald S, Peters J, Venner M, Siegmund W: LC-MS/MS method for the simultaneous determination of clarithromycin, rifampicin and their main metabolites in horse plasma, epithelial lining fluid and broncho-alveolar cells. Pharm Biomed Anal 2011, 55:194-201.

  • Oswald S, Terhaag B, Siegmund W: In vivo probes of drug transport: commonly used probe drugs to assess function of intestinal P-glycoprotein (ABCB1) in humans. Handb Exp Pharmacol 2011, 403-447.

  • Laechelt S, Turrini E, Ruehmkorf A, Siegmund W, Cascorbi I, Haenisch S: Impact of ABCC2 haplotypes on transcriptional and posttranscriptional gene regulation and function Pharmacogenomics J 2011, 11:25-34.


2010
  • Mandery K, Bujok K, Schmidt I, Keiser M, Siegmund W, Balk B, Konig J, Fromm MF, Glaeser H: Influence of the flavonoids apigenin, kaempferol, and quercetin on the function of organic anion transporting polypeptides 1A2 and 2B1. Biochem Pharmacol 2010, 80:1746-1753.

  • Hanke U, May K, Rozehnal V, Nagel S, Siegmund W, Weitschies W: Commonly used nonionic surfactants interact differently with the human efflux transporters ABCB1 (p-glycoprotein) and ABCC2 (MRP2). Eur J Pharm Biopharm 2010, 76:260-268.

  • Leonhardt M, Keiser M, Oswald S, Kuhn J, Jia J, Grube M, Kroemer HK, Siegmund W, Weitschies W: Hepatic uptake of the magnetic resonance imaging contrast agent Gd-EOB-DTPA: role of human organic anion transporters. Drug Metab Dispos 2010, 38:1024-1028.

  • Siegmund W, Sillen U, Lackgren G, Schnabel F, Murtz G, Feustel C: Pharmacokinetics and pharmacodynamics of propiverine in children aged between 5 and 10 years with symptoms of overactive bladder. Clin Pharmacokinet 2010, 49:335-342.

  • Kock K, Koenen A, Giese B, Fraunholz M, May K, Siegmund W, Hammer E, Volker U, Jedlitschky G, Kroemer HK, Grube M: Rapid modulation of the organic anion transporting polypeptide 2B1 (OATP2B1, SLCO2B1) function by protein kinase C-mediated internalization. J.Biol.Chem. 2010, 285:11336-11347.

  • Oswald S, Nassif A, Modess C, Keiser M, Hanke U, Engel A, Lutjohann D, Weitschies W, Siegmund W: Pharmacokinetic and pharmacodynamic interactions between the immunosuppressant sirolimus and the lipid-lowering drug ezetimibe in healthy volunteers. Clin Pharmacol Ther. 2010, 87:663-667.

  • Oswald S, May K, Rosin J, Lutjohann D, Siegmund W: Synergistic influence of Abcb1 and Abcc2 on disposition and sterol lowering effects of ezetimibe in rats. J.Pharm.Sci. 2010, 99:422-429.

  • Rosskopf D, Meyer zu Schwabedissen HE, Kroemer HK, Siegmund W: [Pharmacogenomics in routine medical care]. Dtsch.Med.Wochenschr. 2010, 135:133-144.

  • Venner M, Peters J, Hohensteiger N, Schock B, Bornhorst A, Grube M, Adam U, Scheuch E, Weitschies W, Rosskopf D, Kroemer HK, Siegmund W: Concentration of the macrolide antibiotic tulathromycin in broncho-alveolar cells is influenced by comedication of rifampicin in foals. Naunyn Schmiedebergs Arch.Pharmacol 2010, 381:161-169.

  • Weymar M, Low A, Modess C, Engel G, Grundling M, Petersmann A, Siegmund W, Hamm AO: Propranolol selectively blocks the enhanced parietal old/new effect during long-term recollection of unpleasant pictures: a high density ERP study. Neuroimage 2010, 49:2800-2806.


2009
  • Guo Y, Kock K, Ritter CA, Chen ZS, Grube M, Jedlitschky G, Illmer T, Ayres M, Beck JF, Siegmund W, Ehninger G, Gandhi V, Kroemer HK, Kruh GD, Schaich M: Expression of ABCC-type nucleotide exporters in blasts of adult acute myeloid leukemia: relation to long-term survival. Clin Cancer Res. 2009, 15:1762-1769.

  • Kuhn JP, Hegenscheid K, Siegmund W, Froehlich CP, Hosten N, Puls R: Normal dynamic MRI enhancement patterns of the upper abdominal organs: gadoxetic acid compared with gadobutrol. AJR Am.J.Roentgenol. 2009, 193:1318-1323.

  • May K, Grube M, Malhotra I, Long CA, Singh S, Mandaliya K, Siegmund W, Fusch C, Schneider H, King CL: Antibody-dependent transplacental transfer of malaria blood-stage antigen using a human ex vivo placental perfusion model. PLoS.One. 2009, 4:e7986.

  • Methling K, Reszka P, Lalk M, Vrana O, Scheuch E, Siegmund W, Terhaag B, Bednarski PJ: Investigation of the in vitro metabolism of the analgesic flupirtine. Drug Metab Dispos. 2009, 37:479-493.

  • Niessen J, Jedlitschky G, Grube M, Bien S, Schwertz H, Ohtsuki S, Kawakami H, Kamiie J, Oswald S, Starke K, Strobel U, Siegmund W, Rosskopf D, Greinacher A, Terasaki T, Kroemer HK: Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin. Drug Metab Dispos. 2009, 37:1129-1137.

  • Oevermann L, Scheitz J, Starke K, Kock K, Kiefer T, Dolken G, Niessen J, Greinacher A, Siegmund W, Zygmunt M, Kroemer HK, Jedlitschky G, Ritter CA: Hematopoietic stem cell differentiation affects expression and function of MRP4 (ABCC4), a transport protein for signaling molecules and drugs. Int.J.Cancer 2009, 124:2303-2311.

  • Pospechova K, Rozehnal V, Stejskalova L, Vrzal R, Pospisilova N, Jamborova G, May K, Siegmund W, Dvorak Z, Nachtigal P, Semecky V, Pavek P: Expression and activity of vitamin D receptor in the human placenta and in choriocarcinoma BeWo and JEG-3 cell lines. Mol.Cell Endocrinol. 2009, 299:178-187.

  • Rosskopf D, Kroemer HK, Siegmund W: [Pharmacokinetic problems in clinical practice: role of drug transporters]. Dtsch.Med.Wochenschr. 2009, 134:345-356.


2008
  • May K, Giessmann T, Wegner D, Oertel R, Modess C, Oswald S, Braeter M, Siegmund W: Oral absorption of propiverine solution and of the immediate and extended release dosage forms: influence of regioselective intestinal elimination. Eur.J.Clin Pharmacol 2008, 64:1085-1092.

  • Weitschies W, Friedrich C, Wedemeyer RS, Schmidtmann M, Kosch O, Kinzig M, Trahms L, Sorgel F, Siegmund W, Horkovics-Kovats S, Schwarz F, Raneburger J, Monnikes H: Bioavailability of amoxicillin and clavulanic acid from extended release tablets depends on intragastric tablet deposition and gastric emptying. Eur.J.Pharm.Biopharm. 2008, 70:641-648.

  • Garbacz G, Wedemeyer RS, Nagel S, Giessmann T, Monnikes H, Wilson CG, Siegmund W, Weitschies W: Irregular absorption profiles observed from diclofenac extended release tablets can be predicted using a dissolution test apparatus that mimics in vivo physical stresses. Eur.J.Pharm.Biopharm. 2008, 70:421-428.

  • Oswald S, König J, Lütjohann D, Giessmann T, Kroemer HK, Rimmbach C, Rosskopf D, Fromm MF, Siegmund W: Disposition of ezetimibe is influenced by polymorphisms of the hepatic uptake carrier OATP1B1. Pharmacogenet Genomics. 2008 Jul:18(7):559-68.

  • Mosyagin I, Runge U, Schroeder HW, Dazert E, Vogelgesang S, Siegmund W, Warzok RW, Cascorbi I: Association of ABCB1 genetic variants 3435C>T and 2677G>T to ABCB1 mRNA and protein expression in brain tissue from refractory epilepsy patients. Epilepsia 2008, 49:1555-1561.

  • Haenisch S, May K, Wegner D, Caliebe A, Cascorbi I, Siegmund W: Influence of genetic polymorphisms on intestinal expression and rifampicin-type induction of ABCC2 and on bioavailability of talinolol. Pharmacogenet Genomics. 2008 Apr18(4):357-65

  • May K, Westphal K, Giessmann T, Wegner D, Adam U, Lerch MM, Oertel R, Warzok RW, Weitschies W, Braeter M, Siegmund W: Disposition and antimuscarinic effects of the urinary bladder spasmolytics propiverine: influence of dosage forms and circadian-time rhythms. J Clin Pharmacol. 2008 May48(5):570-9

  • May K, Minarikova V, Linnemann K, Zygmunt M, Kroemer HK, Fusch C, Siegmund W: Role of the multidrug transporter proteins ABCB1 and ABCC2 in the diaplacental transport of talinolol in the term human placenta. Drug Metab Dispos. 2008 Apr36(4):740-4


2007
  • Oswald S, Grube M, Siegmund W, Kroemer HK: Transporter-mediated uptake into cellular compartments. Xenobiotica 2007:37:1171-95

  • Oswald S, Koll C, Siegmund W: Disposition of the cholesterol absorption inhibitor ezetimibe in mdr1a/b (-/-) mice. .Pharm.Sci. 2007:96:3478-84

  • Schmiedl S, Szymanski J, Rottenkolber M, Drewelow B, Haase G, Hippius M, Reimann IR, Siegmund W, May K, Haack S, Hasford J, Thurmann PA: [Analysis of hospital admissions associated with digitalis glycosides.]. Med.Klin.(Munich) 2007:102:603-611

  • Hermann R, Siegmund W, Giessmann T, Westphal K, Weinbrenner A, Hauns B, Reutter F, Lahu G, Zech K, Bethke TD: The oral, once-daily phosphodiesterase 4 inhibitor roflumilast lacks relevant pharmacokinetic interactions with inhaled budesonide. J.Clin Pharmacol 2007:47:1005-1013

  • Scheuch E, Spieker J, Venner M, Siegmund W: Quantitative determination of the macrolide antibiotic tulathromycin in plasma and broncho-alveolar cells of foals using tandem mass spectrometry. J.Chromatogr.B Analyt.Technol.Biomed.Life Sci. 2007:850:464-470

  • Haenisch S, Zimmermann U, Dazert E, Wruck CJ, Dazert P, Siegmund W, Kroemer HK, Warzok RW, Cascorbi I: Influence of polymorphisms of ABCB1 and ABCC2 on mRNA and protein expression in normal and cancerous kidney cortex. Pharmacogenomics.J. 2007:7:56-65

  • Oertel R, Kilian B, Siegmund W, Kirch W: Determination of propiverine and its metabolites in rat samples by liquid chromatography-tandem mass spectrometry. J.Chromatogr.A 2007:1149:121-126


2006
  • Grube M, Kock K, Oswald S, Draber K, Meissner K, Eckel L, Bohm M, Felix SB, Vogelgesang S, Jedlitschky G, Siegmund W, Warzok R, Kroemer HK: Organic anion transporting polypeptide 2B1 is a high-affinity transporter for atorvastatin and is expressed in the human heart. Clin Pharmacol Ther. 2006:80:607-620

  • Bethke TD, Giessmann T, Westphal K, Weinbrenner A, Hauns B, Hauschke D, David M, Lahu G, Zech K, Hermann R, Siegmund W: Roflumilast, a once-daily oral phosphodiesterase 4 inhibitor, lacks relevant pharmacokinetic interactions with inhaled salbutamol when co-administered in healthy subjects. Int.J.Clin Pharmacol Ther. 2006:44:572-579

  • Thurmann PA, Haack S, Werner U, Szymanski J, Haase G, Drewelow B, Reimann IR, Hippius M, Siegmund W, May K, Hasford J: Tolerability of beta-blockers metabolized via cytochrome P450 2D6 is sex-dependent. Clin Pharmacol Ther. 2006:80:551-553

  • Oswald S, Giessmann T, Luetjohann D, Wegner D, Rosskopf D, Weitschies W, Siegmund W: Disposition and sterol-lowering effect of ezetimibe are influenced by single-dose coadministration of rifampin, an inhibitor of multidrug transport proteins. JClin Pharmacol Ther. 2006:Nov;80(5):477-85

  • Oswald S, Westrup S, Grube M, Kroemer HK, Weitschies W, Siegmund W: Disposition and sterol-lowering effect of ezetimibe in multidrug resistance-associated protein 2-deficient rats. J Pharmacol Exp Ther. 2006:Sep;318(3):1293-9

  • Oswald S, Scheuch E, Cascorbi I, Siegmund W: A LC-MS/MS method to quantify the novel cholesterol lowering drug ezetimibe in human serum, urine and feces in healthy subjects genotyped for SLCO1B1. J Chromatogr B Analyt Technol Biomed Life Sci 2006:830(1):143-150

  • Oswald S, Haenisch S, Fricke C, Sudhop T, Remmler C, Giessmann T, Jedlitschky G, Adam U, Schröder E, Warzok R W, Wacke W, Cascorbi I, Kroemer H K, Weitschies W, von Bergmann K, Siegmund W: Intestinal expression of P-glykoprotein (ABCB1), multidrug resistance associated protein 2 (ABCC2), and uridine diphosphate-glucuronosyltransferase 1A1 predicts the disposition and modulates the effects of the cholesterol absorption inhibitor ezetimibe in humans. CLIN PHARMACOL THER 2006:79(3):206-217

  • Bernsdorf A, Giessmann T, Modess C, Wegner D, Igelbrink S, Hecker U, Haenisch S, Cascorbi I, Terhaag B, Siegmund W: Simvastatin does not influence intestinal P-glycoprotein and MRP2 and disposition of talinolol after chronic medication in healthy subjects. BRIT J CLIN PHARMACO 2006:61(4):440-450


2005
  • Weitschies W, Bernsdorf A, Giessmann T, Zschiesche M, Modess C, Hartmann V, Mrazek C, Wegner D, Nagel S, Siegmund W: The talinolol double-peak phenomenon is likely caused by presystemic processing after uptake from gut lumen. Pharm Res 2005:22:5:728-735

  • Moritz KU, Walter R, May K, Giessmann T, Siegmund W: The anticholinergic drug propiverine inhibits the protein kinase C activity in the rat urinary bladder. Pharmazie 2005:60:1:49-51


2004
  • Giessmann T, May K, Modess C, Wegner D, Hecker U, Zschiesche M, Dazert P, Grube M, Schroeder E, Warzok R, Cascorbi I, Kroemer HK, Siegmund W: Carbamazepine regulates intestinal P-glycoprotein and multidrug resistance protein MRP2 and influences disposition of talinolol in humans. Clin Pharmacol Ther 2004:76:3:192-200

  • Giessmann T, Modess C, Hecker U, Zschiesche M, Dazert P, Kunert-Keil C, Warzok R, Engel G, Weitschies W, Cascorbi I, Kroemer HK, Siegmund W: CYP2D6 genotype and induction of intestinal drug transporters by rifampin predict presystemic clearance of carvedilol in healthy subjects. Clin Pharmacol Ther 2004:75:3:213-222

  • Siegmund W, Spieker K, Weike AI, Giessmann T, Modess C, Dabers T, Kirsch G, Sanger E, Engel G, Hamm AO, Nauck M, Meng W: Replacement therapy with levothyroxine plus triiodothyronine (bioavailable molar ratio 14 : 1) is not superior to thyroxine alone to improve well-being and cognitive performance in hypothyroidism. Clin Endocrinol (Oxf) 2004:60:6:750-757


2003
  • Siegmund W, Ludwig K, Engel G, Zschiesche M, Franke G, Hoffmann A, Terhaag B, Weitschies W: Variability of intestinal expression of P-glycoprotein in healthy volunteers as described by absorption of talinolol from four bioequivalent tablets. J Pharm Sci 2003:92:3:604-610

  • Walter R, Ullmann C, Thummler D, Siegmund W: Influence of propiverine on hepatic microsomal cytochrome p450 enzymes in male rats. Drug Metab Dispos 2003:31:6:714-717

  • Freyse EJ, Giessmann T, Petzke KJ, Knospe S, Engel G, Heinke P, Metges CC, Siegmund W: Effects of fatty acids on hepatic amino acid catabolism and fibrinogen synthesis in young healthy volunteers. Am J Physiol Endocrinol Metab 2003:285:1:E54-E62

  • Siegmund W, Cascorbi I, Weitschies W, Kroemer HK: [Significance of drug transporter for the internal medicine clinic]. Internist (Berl) 2003:44,:2:219-226


2002
  • Siegmund W, Altmannsberger S, Paneitz A, Hecker U, Zschiesche M, Franke G, Meng W, Warzok R, Schroeder E, Sperker B, Terhaag B, Cascorbi I, Kroemer HK: Effect of levothyroxine administration on intestinal P-glycoprotein expression: consequences for drug disposition. Clin Pharmacol Ther 2002:72:3:256-264

  • Siegmund W, Ludwig K, Giessmann T, Dazert P, Schroeder E, Sperker B, Warzok R, Kroemer HK, Cascorbi I: The effects of the human MDR1 genotype on the expression of duodenal P-glycoprotein and disposition of the probe drug talinolol. Clin Pharmacol Ther 2002:72:5:572-583

  • Weinbrenner A, Huneke D, Zschiesche M, Engel G, Timmer W, Steinijans VW, Bethke T, Wurst W, Drollmann A, Kaatz HJ, Siegmund W: Circadian rhythm of serum cortisol after repeated inhalation of the new topical steroid ciclesonide. J Clin Endocrinol Metab 2002:87:5:2160-2163

  • Zschiesche M, Lemma GL, Klebingat KJ, Franke G, Terhaag B, Hoffmann A, Gramatte T, Kroemer HK, Siegmund W: Stereoselective disposition of talinolol in man. J Pharm Sci 2002:91:2:303-311

  • Siegmund W, Giessmann T: Requirements concerning antiseptics for periorbital, orbital and intraorbital application. Systemic tolerance of antiseptics used in ophthalmology. Dev Ophthalmol 2002:33:57-65


2001-1991
  • Siegmund W: Reply. Clin Pharmacol Ther 2001:69:1:80-81

  • Weitschies W, Siegmund W: [The challenge of patient consultation and pharmaceutical development: bisphosphonate in solid dosage forms]. Pharm Unserer Zeit 2001:30:6:536-540

  • Westphal K, Weinbrenner A, Zschiesche M, Franke G, Knoke M, Oertel R, Fritz P, von Richter O, Warzok R, Hachenberg T, Kauffmann HM, Schrenk D, Terhaag B, Kroemer HK, Siegmund W: Induction of P-glycoprotein by rifampin increases intestinal secretion of talinolol in human beings: a new type of drug/drug interaction. Clin Pharmacol Ther 2000:68:4:345-355

  • Westphal K, Weinbrenner A, Giessmann T, Stuhr M, Franke G, Zschiesche M, Oertel R, Terhaag B, Kroemer HK, Siegmund W: Oral bioavailability of digoxin is enhanced by talinolol: evidence for involvement of intestinal P-glycoprotein. Clin Pharmacol Ther 2000:68:1:6-12

  • Moritz KU, Walter R, Leopold K, Hadasova E, Engel G, Siegmund W: Interferon- and streptolysin O-induced activation of protein kinases and inhibition of cytochrome P450-dependent monooxygenases in rats. Pharmazie 1998:53:4:268-271

  • Hoffmann C, Zschiesche M, Franke G, Hoffmann A, Terhaag B, Moritz KU, Siegmund W: A single and multiple dose bioavailability study with carbamazepine 400 mg retard tablets with reference to enzyme autoinduction and circadian time differences. Int J Clin Pharmacol Ther 1997:35:11:496-503

  • Walter R, Siegmund W, Scheuch E: Effects of interferon-gamma and streptolysin O on hepatic procainamide N-acetyltransferase and various microsomal cytochrome P450-dependent monooxygenases in rats. Immunopharmacol Immunotoxicol 1996:18:4:571-586

  • Hadasova E, Franke G, Zschiesche M, Ceskova E, Zelenkova O, Siegmund W: Debrisoquine 4-hydroxylation and sulphamethazine N-acetylation in patients with schizophrenia and major depression. Br J Clin Pharmacol 1996:41:5:428-431

  • Scheuch E, Walter R, Hadasova E, Amon I, Siegmund W: Influence of H2-receptor- and proton pump inhibitors on some functions of the oxydative and conjugative drug metabolism. Pharmazie 1996:51:7:493-497

  • Walter R, Hadasova E, Scheuch E, Siegmund W: Effects of streptolysin O, polyriboinosinic-polyribocytidylic acid and combinations with cyclophosphamide on the hepatic arylamine N-acetyltransferase and cytochrome P450-dependent monooxygenases in rats. Pharmazie 1996:51:7:498-500

  • Hadasova E, Siegmund W, Walter R, Scheuch E, Franke G: Effects of streptolysin O, picibanil (OK 432) and interferon alpha 2A on cytochrome P-450-dependent monooxygenases and arylamine N-acetyltransferase in rat liver. Immunopharmacol Immunotoxicol 1995:17:2:283-300

  • Moritz KU, Walter R, Franke G, Siegmund W: Circadian-time rhythm of hepatic protein kinase C of rats pretreated with phenobarbital. Pharmazie 1995:50:3:211-2133

  • Franke G, Diletti E, Hoffmann C, Zschiesche M, Scheuch E, Siegmund W: Relative bioavailability of different valproic acid formulations. Int J Clin Pharmacol Ther 1995:33:12:653-657

  • Siegmund W, Zschiesche M, Franke G, Amon I: Effects of nocloprost clathrate on absorption of acetylsalicylic acid. Int J Clin Pharmacol Ther 1994:32:1:51-57

  • Siegmund W, Wolfle G, Franke G, Amon I: Effects of nocloprost on some monooxygenases of rat and human liver. Arzneimittelforschung 1993:43:10:1076-1078

  • Muller C, Siegmund W, Huupponen R, Kaila T, Franke G, Iisalo E, Zschiesche M: Kinetics of propiverine as assessed by radioreceptor assay in poor and extensive metabolizers of debrisoquine. Eur J Drug Metab Pharmacokinet 1993:18:3:265-272

  • Siegmund W, Scheuch E, Zschiesche M, Franke G, Stolz E, Amon I: Potential pharmacokinetic interactions of nocloprost clathrate with retarded theophylline and enteric coated diclofenac after single and repeated premedication in healthy volunteers. Int J Clin Pharmacol Ther Toxicol 1993,:31:8:407-414

  • Siegmund W, Zschiesche M, Franke G, Muller C, Amon I: Effects of nocloprost (9 beta-chloro-16,16-dimethyl PG E2) on absorption and disposition of antipyrine and sulfamethazine in healthy volunteers. Int J Clin Pharmacol Ther Toxicol 1993:31:4:190-197

  • Zeruesenay D, Siegmund W, Franke G, Zschiesche M: Circadian time-dependent kinetics of theophylline and its modulation by phenobarbital pretreatment in rats. Chronobiol Int 1993:10:2:81-86

  • Siegmund W, Fengler JD, Franke G, Zschiesche M, Eike O, Eike E, Meisel P, Wulkow R: N-acetylation and debrisoquine hydroxylation polymorphisms in patients with Gilbert's syndrome. Br J Clin Pharmacol 1991:32:4:467-472