Members
- Chia-Jung Busch, MD, Prof (PI)
- Markus Blaurock, MD (PI)
- Christian Scharf, PhD (PI)
- Martin Wilhelm (Study Coordinator)
- Jose Gonzalez, MD (PostDoc)
- Anne Jüngling (TA)
- Maria Dib, MD (Grad Student)
- Dadash Babirsoy, MD (Grad Doctorate Student)
- Olaf Gil, MD (Grad Student)
- Sarah Rosenwirth (Grad Student)
- Leonie Huckschlag (Grad Student)
- Mareile Schröder (Grad Student)
Affiliation
Department of Otorhinolaryngology, Head and Neck Surgery, UMG
Abstract
Our workgroup focuses on four main areas of interest:
- Clinical trials: in phase II, III and IV: testing new pharmaceutical drugs and devices in tumor therapy. We have an active clinical trials unit and study pipeline.
- Clinical trials (non-pharmaceutical): Our focus is mainly on enhanced recovery after surgery and prehabilitation as well as sleep apnea in head and neck cancer patients during and after treatment.
- Endoscope based cold atmospheric plasma therapy: We are exploring the application of cold atmospheric plasma via a flexible endoscopic platform both in vitro and in vivo. Our focus is on physiological effects and molecular mechanisms on tumor cells and healthy tissue.
- Development of tumor embedded nasal mucosal organoids: This platform allows for exploring complex interaction of tumor cells within the mucosal system including ciliary activity, drug transporting ability and immune activation processes. We aim to develop a model system for plasma-based tumor therapy and drug interaction.
Key techniques
- Advanced organoid cell culturing
- Proteomic and transcriptomic workflows
- Mucosal tissue wound models for the evaluation of mucosal viability and wound healing ability
- Frozen and paraffin embedded tissue sectioning and IHC
- Advanced biometrics and fitness evaluation
- Study pipeline for clinical trials including biomaterial processing
Special lab equipment
Proteomics pipeline, mass spectrometry (MALDI-TOF, Triple Quad), cryo- and rotation microtomes, data and network analysis
We seek cooperation in the field of
Bioinformatics, NGS, Advanced Microscopy, Metabolomics, 3D cell culture systems
