This subgroup focuses on the synthesis of biologically active compounds for the modulation of Endoplasmic-reticulum-associated protein degradation (ERAD). Structural variations will be explored on the basis of known lead structures which possess improvable activity and selectivity. The derivatization will apply modern catalytic reactions that are beyond the standard repertoire of classic organic synthesis.
The longstanding expertise in the field of synthetic organic chemistry and the application of homogeneous and heterogeneous catalyst systems represent an important pillar within the PePPP research network. The catalytic functionalization of organic compounds enables an efficient and eco-friendly synthesis of synthetically useful and medicinally-relevant target structures. In addition to the use of established systems for the catalytic carbonylation, trifluoroalkylation and hydrofunctionalization, special efforts will be made to investigate photochemical functionalization reactions through direct cleavage of C-H bonds as well as the transition metal-catalyzed stereoselective difunctionalization of olefins.
All synthesized compounds will be made available to the project partners for pharmacological testing. Within the interdisciplinary research cluster, new structural variations can be discussed in time to streamline further optimizations. Successfully tested active ingredients could provide the basis for new therapeutic approaches for treating hereditary liver and pancreas diseases.
Supervisors
Prof. Dr. rer. nat. Matthias Beller
Team
Former employees