Members:
Sandrine Sander, MD PhD (PI)
Nicole Schröder (TA)
Carolin Brombach (Grad Student)
Research focus:
Our focus is on mechanistic insights in B cell transformation. By generating conditional mouse mutants recapitulating human B cell lymphomagenesis, we identify novel oncogenes driving lymphomagenesis, but also challenge our understanding of (B cell) immunology including B cell specific DNA mutagenesis and survival signals. Recent projects make use of our unique collection of autochthonous B cell lymphoma models to study the impact of the immune system on tumorigenesis. In summary, our work aims to provide detailed functional analyses to explain lymphomagenesis and pave the way for enhanced efficacy and specificity in lymphoma therapy.
Key techniques:
• Lymphoma models based on conditional mouse mutants
• (Mouse) B cell characterization by flow cytometry and functional assays
• Immunofluorescence microscopy in mouse lymphoid tissue
