Dipl.-Ing. (FH) Annette Wegner
Klinik für Anästhesie, Intensiv,- Notfall- und Schmerzmedizin
Universitätsmedizin Greifswald
Ferdinand-Sauerbruch-Straße
17475 Greifswald
Tel. 03834 86 5807
Fax 03834 86 5894
Annette.Wegner@med.uni-greifswald.de
Sabine Will
Klinik für Anästhesie, Intensiv,- Notfall- und Schmerzmedizin
Universitätsmedizin Greifswald
Ferdinand-Sauerbruch-Straße
17475 Greifswald
Tel. 03834 86 5848
Fax 03834 86 5894
Sabine.Will@med.uni-greifswald.de
Research of the unit consists in basic research encompassing vascular and respiratory responses to physical injury, inflammation (in particular sepsis), and organism or organ responses to the interventions and the agents used in Anesthesia, Emergency department, and in the ICU in the patient management, in particular in multiple organ failure.
The principal cell and organ systems investigated are:
The principal experimental methods used:
A. Responses of the cardiovascular system, including local microcirculation, to inflammation and anaesthesia.
1. Modulation of bowel microcirculation in the septic rat model
The purpose of this study will be to examine, using intravital microscopy of the rat bowel microcirculation, vasodilator therapy, anti-inflammatory agents, and the effects of modulation of tyrosine kinase/phosphatise in septic conditions. These data also may explain the mechanism of the protective effect of some agents used in therapy of acute vascular pathologies, effects on the bowel anastomosis healing, and eventually contribution of specific peripheral vasodilatation to those beneficial effects.
Principal Faculty: PD Dr. med. habil. Dragan Pavlovic
Investigators: Daniel Sprecher, Stefan Lütche, Daniel Austen
&nb
Peripheral circulation disturbance, vascular hyporeactivity, and tissue hypoperfusion plays a major role in the pathogenesis of ongoing sepsis and multiple organ dysfunction syndrome (MODS). In animal models of sepsis induced by endotoxin it has been shown that various anti-inflammatory agents, or vasodilators could partially bring about normal reactivity of the arteries. To further investigate mechanisms involved in vascular motility in LPS induced endotoxemai in rat we will examine in vitro reactivity of aortic segments to various vasodilators, anti-inflammatory agents as well as modulation of tyrosine phosphorilation, which potentially could be relevant in therapy.
Principal Faculty: PD Dr. med. habil. Dragan Pavlovic
Investigator: Stefan Lütche
B. Responses of the respiratory system to inflammation and anaesthesia
1. Effects of potassium channel activators, calcium blockers and modulation of tyrosine phosphorilation on smooth muscle contraction
Potassium channel activators hyperpolarise smooth muscle membrane and relax the smooth muscle. They are effective as vascular smooth muscle relaxant and have been extensively used as therapeutic agents for the treatment of hypertension. Nevertheless, there use as airway smooth muscle relaxation in bronchial hyperreactivity has been limited. They have been either without effect or less effective then yet available beta 2 agonists, or, sometimes accompanied by undesirable effects. In this study we will examine some yet not sufficiently explored potassium channel activators or Ca++ blockers.
Principal Faculty: PD Dr. med. habil. Dragan Pavlovic
Investigator:
